RESEARCH INTO ACC
The ACC fund at the Get A Head Charitable Trust supports research that will change the lives of patients with adenoid cystic carcinoma (ACC) for the better. Get A-Head collaborates closely with the Adenoid Cystic Carcinoma Research Foundation (ACCRF) in the US to fund the highest-impact projects run by world-renowned scientists. In just the past five years, ACCRF-affiliated researchers have made enormous strides in understanding the disease and moving toward better treatments. Some of the highlights include:
- Development of bio-repositories that, for the first time, make ACC tumor specimens available to scientists for study worldwide
- Identification of a DNA chromosomal translocation in most ACC tumors that is the likely cause of the disease
- Analysis of molecular targets that may include the “Achilles’ heel” of ACC
- Creation of the first mouse models of ACC to test the effectiveness of drugs
- Coordination of the first ACC clinical trial of a targeted therapy with a clear scientific rationale
This remarkable and rapid scientific progress is creating excitement among ACC patients and researchers. However, there is still a long road to travel before there is a cure. More research must be funded to understand the mechanisms and vulnerabilities of ACC. In the coming year, one of the most pressing research projects is the ACC Exome sequencing Project run at the Sanger Institute, Hinxton, UK. Dr. Andrew Futreal will identify new molecular targets for therapy by sequencing all protein-encoding DNA (20,000 or so genes) in ACC tumor specimens. Finding the DNA “misspellings” that cause ACC will permit researchers to better select and design drugs to counteract the effects of these misspellings. Also, there have been some considerable developments made in specific ACC trials at the Institute of Cancer Research in London and we hope to support further progess in these efforts as well. There are also encouraging developments that ACCRF have made us aware of in the US and it is a great help for us to be able to funnel monies directly to the UK-based research mentioned above, which frees up their funds for these local projects.
THE FUNDS RAISED THAT WERE RAISED FOR THE LEJOG CAMPAIGN IN 2010 AND THOSE THAT WE RAISE ON JOGLE THIS YEAR HAVE BEEN EAR-MARKED FOR THE EXOME SEQUENCING PROJECT IN CAMBRIDGE. WE ALSO PLAN TO SET SOME OF THE FUNDING ASIDE TO SEE HOW THE ICR RESEARCH PROGRESSES OVER THE NEXT COUPLE OF MONTHS.
YOUR DONATIONS WILL FUND THESE RESEARCH EFFORTS DIRECTLY – THANK YOU!